Considerations in the Construction of a New Preclinical Facility
Many aspects need to be considered in details before construction of a new preclinical facility. These aspects include requirements in relation to international guidelines for preclinical studies, Good Laboratory Practice, barriers, animal welfare legislation, occupational health and customer expectations. This article describes some of the most important elements that should be considered in this respect, seen in the light of drug development.
It should be remembered that detailed individual plans are always required for each specific facility for the following reasons. Legislative discrepancies between countries may influence the final design of a facility from one country to another. In addition, different types of work may be undertaken by each individual laboratory, leading to various needs for each site. Furthermore, as working routines to some extent are usually site-specific, this may also influence the optimal construction between laboratories. This article should therefore be seen as a guide to thoughts that should be made before construction of a new facility. It is not the intention that it should be used as a detailed check-list.